Oral steroids enhance epithelial repair in nasal polyposis via up-regulation of AP-1 gene network
نویسندگان
چکیده
1 Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 2 Department of Pediatrics, University of California San Diego, La Jolla, California 3 Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yet-Sen University, Guangzhou, China 4 Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
منابع مشابه
Oral steroids enhance epithelial repair in nasal polyposis via upregulation of the AP-1 gene network.
BACKGROUND Chronic mucosal inflammation, epithelial damage and aberrant tissue remodelling are common features in nasal polyposis (NP). A study was undertaken to characterise the gene expression profile in NP tissues and to explore the molecular mechanisms underlying the ameliorative effects of glucocorticosteroids (GCs) in NP. METHODS Two sets of NP biopsies (before and after GC treatment) w...
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Background: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). Objective: To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. Methods: A cross sectional multicenter study was d...
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Nasal polyposis (NP) has a great impact on quality of life (QOL) and its management involves a combination of medical therapy and surgery. To the authors' knowledge, no publication has extensively examined NP after optimal medical treatment based on subjective evaluations. The aim of this prospective study was designed to evaluate the QOL in NP patients after (1) a short course of oral steroids...
متن کاملDoes oral prednisolone increase the efficacy of subsequent nasal steroids in treating nasal polyposis?
BACKGROUND Although combined oral and nasal steroid therapy is widely used in nasal polyposis, a subset of patients show an unfavorable therapeutic outcome. This study aimed to evaluate whether oral prednisolone produces any additive effects on subsequent nasal steroid therapy and to evaluate if any clinical variables can predict therapeutic outcome. METHODS Using a 3:2 randomization ratio, ...
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تاریخ انتشار 2009